| Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. | |
| Reference Price: | $50.00 Click to Order |
| More Information: | GA - CAS [30562-34-6] - C29H40N2O9 - Cancer Research - Antibiotic - oney A, Workman P. - HSP90 as a new therapeutic target for cancer therapy: the story unfolds. - Expert Opin Biol Ther. - Blagosklonny MV. - Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. - Leukemia. - Ochel HJ, Eichhorn K, Gademann G., - Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones. - Cell Stress Chaperones. - 4. Neckers L, Schulte TW, Mimnaugh E. - Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity - Invest New Drugs. - Cardenas ME, Sanfridson A, Cutler NS, Heitman J - Signal-transduction cascades as targets for therapeutic intervention by natural products. - Trends Biotechnol. - Scheibel T, Buchner J. - The Hsp90 complex--a super-chaperone machine as a novel drug target. - Biochem Pharmacol. |
| Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. | |
| Reference Price: | $50.00 Click to Order |
| More Information: | GA - CAS [30562-34-6] - C29H40N2O9 - Cancer Research - Angiogenesis - oney A, Workman P. - HSP90 as a new therapeutic target for cancer therapy: the story unfolds. - Expert Opin Biol Ther. - Blagosklonny MV. - Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. - Leukemia. - Ochel HJ, Eichhorn K, Gademann G., - Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones. - Cell Stress Chaperones. - 4. Neckers L, Schulte TW, Mimnaugh E. - Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity - Invest New Drugs. - Cardenas ME, Sanfridson A, Cutler NS, Heitman J - Signal-transduction cascades as targets for therapeutic intervention by natural products. - Trends Biotechnol. - Scheibel T, Buchner J. - The Hsp90 complex--a super-chaperone machine as a novel drug target. - Biochem Pharmacol. |
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