Rubromycin, Streptomyces Sp.
Rubromycin, <i>Streptomyces</i> Sp. A quinone antibiotic that inhibits HIV-1 reverse transcriptase (RT). Cytostatically active against different tumor cell lines. Inhibits Human telomerase.
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More Information:C27H20O12 - Cancer Research - Antibiotic - Ueno, T. - Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. - Biochemistry. - Goldman, M.E. et al. - Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. - Mol Pharmacol. - Brockmann, H. et al. - The structure of rubromycin. - Tetrahedron Lett. - 4. Merck Index.

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