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Herbimycin H-1050
Streptomyces Hygroscopicus
Herbimycin A is a benzoquinoid ansamycin antibiotic that acts a cell permeable inhibitor of tyrosine kinase and inducer of Heat Shock Proteins. Herbimycin A demonstrates anti-angiogenesis activity and also increases the sensitivity of certain cancer cells to chemotherapeutic agents.
Product No: H-1050
Chemical Formula: C30H42N2O9
M.W.: 574.66
CAS No: [70563-58-5]
Handling: Toxic, Hygroscopic
Storage: +4°C
Material Saftey Data Sheet
Certificate of Analysis
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Literature References
- 1. Geldanamycin and herbimycin A induce apoptotic
killing of B chronic lymphocytic leukemia cells and augment the cells'
sensitivity to cytotoxic drugs. Jones DT, Addison E, North JM, Lowdell MW,
Hoffbrand AV, Mehta AB, Ganeshaguru K, Folarin NI, Wickremasinghe RG. Blood.
2004 Mar 1;103(5):1855-61. Epub 2003 Oct 23.
- 2. Herbimycin A induces sympathetic neuron survival and
protects against hypoxia. Cabral-Da-Silva MC, Loureiro Dos Santos NE, De Mello
FG, Taylor JS, Tolkovsky AM, Linden R, Reis RA. Neuroreport. 2003 Dec
19;14(18):2397-401.
- 3. Herbimycin A induces G1 arrest through accumulation
of p27(Kip1) in cyclin D1-overexpressing fibroblasts. Endo N, Tashiro E,
Umezawa K, Kawada M, Uehara Y, Doki Y, Weinstein IB, Imoto M. Biochem Biophys
Res Commun. 2000 Jan 7;267(1):54-8.
- 4. Benzoquinoid ansamycins (herbimycin A and
geldanamycin) interfere with the maturation of growth factor receptor tyrosine
kinases. Sakagami M, Morrison P, Welch WJ. Cell Stress Chaperones. 1999
Mar;4(1):19-28.
- 5. Herbimycin A enhances apoptotic effect of
chemotherapeutic drugs on K562 cells. Ren H, Chen S, Lu D. Chin Med J (Engl).
1998 Aug;111(8):678-81.
- 6. A new activity of herbimycin A: inhibition of
angiogenesis. Yamashita T, Sakai M, Kawai Y, Aono M, Takahashi K. J Antibiot
(Tokyo). 1989 Jun;42(6):1015-7.
- 7. Herbimycin, a new antibiotic produced by a strain of Streptomyces. Omura S, Iwai Y, Takahashi Y, Sadakane N, Nakagawa A, Oiwa H, Hasegawa Y, Ikai T. J Antibiot (Tokyo). 1979 Apr;32(4):255-61.